Structural and functional analysis of the human POT1-TPP1 telomeric complex

POT1 and TPP1 are part of the shelterin complex and are essential for telomere length regulation and maintenance. Naturally occurring mutations of the telomeric POT1–TPP1 complex are implicated in familial glioma, melanoma and chronic lymphocytic leukaemia. Here we report the atomic structure of the...

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Detalles Bibliográficos
Autores principales: Rice, Cory, Shastrula, Prashanth Krishna, Kossenkov, Andrew V., Hills, Robert, Baird, Duncan M., Showe, Louise C., Doukov, Tzanko, Janicki, Susan, Skordalakes, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394233/
https://www.ncbi.nlm.nih.gov/pubmed/28393830
http://dx.doi.org/10.1038/ncomms14928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394233/
https://www.ncbi.nlm.nih.gov/pubmed/28393830
http://dx.doi.org/10.1038/ncomms14928

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