Crystal structure of Zen4 in the apo state reveals a missing conformation of kinesin

Kinesins hydrolyse ATP to transport intracellular cargoes along microtubules. Kinesin neck linker (NL) functions as the central mechano-chemical coupling element by changing its conformation through the ATPase cycle. Here we report the crystal structure of kinesin-6 Zen4 in a nucleotide-free, apo st...

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Detalles Bibliográficos
Autores principales: Guan, Ruifang, Zhang, Lei, Su, Qian Peter, Mickolajczyk, Keith J., Chen, Geng-Yuan, Hancock, William O., Sun, Yujie, Zhao, Yongfang, Chen, Zhucheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394238/
https://www.ncbi.nlm.nih.gov/pubmed/28393873
http://dx.doi.org/10.1038/ncomms14951

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394238/
https://www.ncbi.nlm.nih.gov/pubmed/28393873
http://dx.doi.org/10.1038/ncomms14951

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