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Investigating the molecular mechanism of positive and negative allosteric modulators in the calcium-sensing receptor dimer

Allosteric modulators that are targeting the calcium-sensing receptor (CaSR) hold great therapeutic potential, and elucidating the molecular basis for modulation would thus benefit the development of novel therapeutics. In the present study, we aimed at investigating the mechanism of allosteric modu...

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Detalles Bibliográficos
Autores principales: Jacobsen, Stine Engesgaard, Gether, Ulrik, Bräuner-Osborne, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394417/
https://www.ncbi.nlm.nih.gov/pubmed/28417952
http://dx.doi.org/10.1038/srep46355