Normally lethal amino acid substitutions suppress an ultramutator DNA Polymerase δ variant

In yeast, the pol3-01,L612M double mutant allele, which causes defects in DNA polymerase delta (Pol δ) proofreading (pol3-01) and nucleotide selectivity (pol3-L612M), confers an “ultramutator” phenotype that rapidly drives extinction of haploid and diploid MMR-proficient cells. Here, we investigate...

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Detalles Bibliográficos
Autores principales: Dennis, Daniel G., McKay-Fleisch, Jill, Eitzen, Kaila, Dowsett, Ian, Kennedy, Scott R., Herr, Alan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394481/
https://www.ncbi.nlm.nih.gov/pubmed/28417960
http://dx.doi.org/10.1038/srep46535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394481/
https://www.ncbi.nlm.nih.gov/pubmed/28417960
http://dx.doi.org/10.1038/srep46535

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