Excitability in the p53 network mediates robust signaling with tunable activation thresholds in single cells

Cellular signaling systems precisely transmit information in the presence of molecular noise while retaining flexibility to accommodate the needs of individual cells. To understand design principles underlying such versatile signaling, we analyzed the response of the tumor suppressor p53 to varying...

Descripción completa

Detalles Bibliográficos
Autores principales: Mönke, Gregor, Cristiano, Elena, Finzel, Ana, Friedrich, Dhana, Herzel, Hanspeter, Falcke, Martin, Loewer, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394551/
https://www.ncbi.nlm.nih.gov/pubmed/28417973
http://dx.doi.org/10.1038/srep46571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394551/
https://www.ncbi.nlm.nih.gov/pubmed/28417973
http://dx.doi.org/10.1038/srep46571

Ejemplares similares