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T cells in chronic lymphocytic leukemia display dysregulated expression of immune checkpoints and activation markers

Chronic lymphocytic leukemia is characterized by impaired immune functions largely due to profound T-cell defects. T-cell functions also depend on co-signaling receptors, inhibitory or stimulatory, known as immune checkpoints, including cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) and progra...

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Detalles Bibliográficos
Autores principales: Palma, Marzia, Gentilcore, Giusy, Heimersson, Kia, Mozaffari, Fariba, Näsman-Glaser, Barbro, Young, Emma, Rosenquist, Richard, Hansson, Lotta, Österborg, Anders, Mellstedt, Håkan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394965/
https://www.ncbi.nlm.nih.gov/pubmed/27927767
http://dx.doi.org/10.3324/haematol.2016.151100