Inhibition of 4EBP phosphorylation mediates the cytotoxic effect of mechanistic target of rapamycin kinase inhibitors in aggressive B-cell lymphomas

Mechanistic target of rapamycin (mTOR) complex 1 is a central integrator of nutrient and growth factor inputs that controls cell growth in eukaryotes. The second generation of mTOR kinase inhibitors (TORKi), directly targeting the mTOR catalytic site, are more effective than rapamycin and its analog...

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Detalles Bibliográficos
Autores principales: Bi, Chengfeng, Zhang, Xuan, Lu, Ting, Zhang, Xiaoyan, Wang, Xianhuo, Meng, Bin, Zhang, Huilai, Wang, Ping, Vose, Julie M., Chan, Wing C., McKeithan, Timothy W., Fu, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395116/
https://www.ncbi.nlm.nih.gov/pubmed/28104700
http://dx.doi.org/10.3324/haematol.2016.159160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395116/
https://www.ncbi.nlm.nih.gov/pubmed/28104700
http://dx.doi.org/10.3324/haematol.2016.159160

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