Tau phosphorylation induced by severe closed head traumatic brain injury is linked to the cellular prion protein

Studies in vivo and in vitro have suggested that the mechanism underlying Alzheimer’s disease (AD) neuropathogenesis is initiated by an interaction between the cellular prion protein (PrP(C)) and amyloid-β oligomers (Aβo). This PrP(C)-Aβo complex activates Fyn kinase which, in turn, hyperphosphoryla...

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Detalles Bibliográficos
Autores principales: Rubenstein, Richard, Chang, Binggong, Grinkina, Natalia, Drummond, Eleanor, Davies, Peter, Ruditzky, Meir, Sharma, Deep, Wang, Kevin, Wisniewski, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395835/
https://www.ncbi.nlm.nih.gov/pubmed/28420443
http://dx.doi.org/10.1186/s40478-017-0435-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395835/
https://www.ncbi.nlm.nih.gov/pubmed/28420443
http://dx.doi.org/10.1186/s40478-017-0435-7

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