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The risk of bias in randomized controlled trials in otorhinolaryngology: hardly any improvement since 1950

BACKGROUND: Randomized Controlled Trials (RCTs) represent the most valuable study design to evaluate the effectiveness of therapeutic interventions. However, flaws in design, conduct, analysis, and reporting of RCTs can cause the effect of an intervention to be under- or overestimated. These biased...

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Detalles Bibliográficos
Autores principales: Peters, Jeroen P. M., Stegeman, Inge, Grolman, Wilko, Hooft, Lotty
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395869/
https://www.ncbi.nlm.nih.gov/pubmed/28428729
http://dx.doi.org/10.1186/s12901-017-0036-x