Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration

An intronic GGGGCC expansion in C9orf72 is the most common known cause of both frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The repeat expansion leads to the generation of sense and antisense repeat RNA aggregates and dipeptide repeat (DPR) proteins, generated by...

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Detalles Bibliográficos
Autores principales: Mizielinska, Sarah, Ridler, Charlotte E., Balendra, Rubika, Thoeng, Annora, Woodling, Nathan S., Grässer, Friedrich A., Plagnol, Vincent, Lashley, Tammaryn, Partridge, Linda, Isaacs, Adrian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395972/
https://www.ncbi.nlm.nih.gov/pubmed/28420437
http://dx.doi.org/10.1186/s40478-017-0432-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395972/
https://www.ncbi.nlm.nih.gov/pubmed/28420437
http://dx.doi.org/10.1186/s40478-017-0432-x

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