Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress

Isothiocyanates, such as phenethyl isothiocyanate (PEITC), are formed following the consumption of cruciferous vegetables and generate reactive oxygen species (ROS) that lead to the induction of cytoprotective genes such as the UDP-glucuronosyltransferases (UGTs). The induction of ROS activates the...

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Detalles Bibliográficos
Autores principales: Yoda, Emiko, Paszek, Miles, Konopnicki, Camille, Fujiwara, Ryoichi, Chen, Shujuan, Tukey, Robert H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395973/
https://www.ncbi.nlm.nih.gov/pubmed/28422158
http://dx.doi.org/10.1038/srep46489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395973/
https://www.ncbi.nlm.nih.gov/pubmed/28422158
http://dx.doi.org/10.1038/srep46489

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