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Dynamic changes in DNA demethylation in the tree shrew (Tupaia belangeri chinensis) brain during postnatal development and aging
Brain development and aging are associated with alterations in multiple epigenetic systems, including DNA methylation and demethylation patterns. Here, we observed that the levels of the 5-hydroxymethylcytosine (5hmC) ten-eleven translocation (TET) enzyme-mediated active DNA demethylation products w...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Science Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396032/ https://www.ncbi.nlm.nih.gov/pubmed/28409505 http://dx.doi.org/10.24272/j.issn.2095-8137.2017.013 |
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author | Wei, Shu Hua, Hai-Rong Chen, Qian-Quan Zhang, Ying Chen, Fei Li, Shu-Qing Li, Fan Li, Jia-Li |
author_facet | Wei, Shu Hua, Hai-Rong Chen, Qian-Quan Zhang, Ying Chen, Fei Li, Shu-Qing Li, Fan Li, Jia-Li |
author_sort | Wei, Shu |
collection | PubMed |
description | Brain development and aging are associated with alterations in multiple epigenetic systems, including DNA methylation and demethylation patterns. Here, we observed that the levels of the 5-hydroxymethylcytosine (5hmC) ten-eleven translocation (TET) enzyme-mediated active DNA demethylation products were dynamically changed and involved in postnatal brain development and aging in tree shrews (Tupaia belangeri chinensis). The levels of 5hmC in multiple anatomic structures showed a gradual increase throughout postnatal development, whereas a significant decrease in 5hmC was found in several brain regions in aged tree shrews, including in the prefrontal cortex and hippocampus, but not the cerebellum. Active changes in Tet mRNA levels indicated that TET2 and TET3 predominantly contributed to the changes in 5hmC levels. Our findings provide new insight into the dynamic changes in 5hmC levels in tree shrew brains during postnatal development and aging processes. |
format | Online Article Text |
id | pubmed-5396032 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Science Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-53960322017-04-24 Dynamic changes in DNA demethylation in the tree shrew (Tupaia belangeri chinensis) brain during postnatal development and aging Wei, Shu Hua, Hai-Rong Chen, Qian-Quan Zhang, Ying Chen, Fei Li, Shu-Qing Li, Fan Li, Jia-Li Zool Res Reports Brain development and aging are associated with alterations in multiple epigenetic systems, including DNA methylation and demethylation patterns. Here, we observed that the levels of the 5-hydroxymethylcytosine (5hmC) ten-eleven translocation (TET) enzyme-mediated active DNA demethylation products were dynamically changed and involved in postnatal brain development and aging in tree shrews (Tupaia belangeri chinensis). The levels of 5hmC in multiple anatomic structures showed a gradual increase throughout postnatal development, whereas a significant decrease in 5hmC was found in several brain regions in aged tree shrews, including in the prefrontal cortex and hippocampus, but not the cerebellum. Active changes in Tet mRNA levels indicated that TET2 and TET3 predominantly contributed to the changes in 5hmC levels. Our findings provide new insight into the dynamic changes in 5hmC levels in tree shrew brains during postnatal development and aging processes. Science Press 2017-03-18 /pmc/articles/PMC5396032/ /pubmed/28409505 http://dx.doi.org/10.24272/j.issn.2095-8137.2017.013 Text en http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Reports Wei, Shu Hua, Hai-Rong Chen, Qian-Quan Zhang, Ying Chen, Fei Li, Shu-Qing Li, Fan Li, Jia-Li Dynamic changes in DNA demethylation in the tree shrew (Tupaia belangeri chinensis) brain during postnatal development and aging |
title | Dynamic changes in DNA demethylation in the tree shrew (Tupaia belangeri chinensis) brain during postnatal development and aging |
title_full | Dynamic changes in DNA demethylation in the tree shrew (Tupaia belangeri chinensis) brain during postnatal development and aging |
title_fullStr | Dynamic changes in DNA demethylation in the tree shrew (Tupaia belangeri chinensis) brain during postnatal development and aging |
title_full_unstemmed | Dynamic changes in DNA demethylation in the tree shrew (Tupaia belangeri chinensis) brain during postnatal development and aging |
title_short | Dynamic changes in DNA demethylation in the tree shrew (Tupaia belangeri chinensis) brain during postnatal development and aging |
title_sort | dynamic changes in dna demethylation in the tree shrew (tupaia belangeri chinensis) brain during postnatal development and aging |
topic | Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396032/ https://www.ncbi.nlm.nih.gov/pubmed/28409505 http://dx.doi.org/10.24272/j.issn.2095-8137.2017.013 |
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