PI3Kβ Inhibitor TGX221 Selectively Inhibits Renal Cell Carcinoma Cells with Both VHL and SETD2 mutations and Links Multiple Pathways

We aimed to exploit novel compounds with high selectivity to clear cell renal cell carcinoma (ccRCC) with common mutations. Using the GDSC databases, we searched for compounds with high selectivity for ccRCC with VHL and/or SETD2 mutations. Clinical impact and gene interactions were analysed using T...

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Detalles Bibliográficos
Autores principales: Feng, Chenchen, Sun, Yang, Ding, Guanxiong, Wu, Zhong, Jiang, Haowen, Wang, Lujia, Ding, Qiang, Wen, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396071/
https://www.ncbi.nlm.nih.gov/pubmed/25853938
http://dx.doi.org/10.1038/srep09465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396071/
https://www.ncbi.nlm.nih.gov/pubmed/25853938
http://dx.doi.org/10.1038/srep09465

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