MEK inhibition appears to improve symptom control in primary NRAS-driven CNS melanoma in children

BACKGROUND: Primary melanoma of the CNS in children is extremely rare, and usually linked to congenital melanocytic naevus syndrome, caused by mosaicism for oncogenic NRAS mutations. Outcome is fatal in all cases. Data from murine and in vitro studies suggest that MEK inhibition is a possible therap...

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Detalles Bibliográficos
Autores principales: Kinsler, Veronica A, O'Hare, Patricia, Jacques, Thomas, Hargrave, Darren, Slater, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396107/
https://www.ncbi.nlm.nih.gov/pubmed/28253523
http://dx.doi.org/10.1038/bjc.2017.49

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396107/
https://www.ncbi.nlm.nih.gov/pubmed/28253523
http://dx.doi.org/10.1038/bjc.2017.49

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