An Efficient Chemoenzymatic Synthesis of Dihydroartemisinic Aldehyde

Artemisinin from the plant Artemisia annua is the most potent pharmaceutical for the treatment of malaria. In the plant, the sesquiterpene cyclase amorphadiene synthase, a cytochrome‐dependent CYP450, and an aldehyde reductase convert farnesyl diphosphate (FDP) into dihydroartemisinic aldehyde (DHAA...

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Detalles Bibliográficos
Autores principales: Demiray, Melodi, Tang, Xiaoping, Wirth, Thomas, Faraldos, Juan A., Allemann, Rudolf K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396139/
https://www.ncbi.nlm.nih.gov/pubmed/28294491
http://dx.doi.org/10.1002/anie.201609557

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396139/
https://www.ncbi.nlm.nih.gov/pubmed/28294491
http://dx.doi.org/10.1002/anie.201609557

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