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Simultaneous generation of multi‐gene knockouts in human cells

Genome‐editing techniques enable the generation of gene knockouts in various mammalian cell lines. However, it remains technically challenging to completely disrupt a targeted gene using a canonical method in a timely manner. To improve the efficiency of producing reliable genomic modifications, we...

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Detalles Bibliográficos
Autores principales: Zhou, Yuexin, Zhang, Hongmin, Wei, Wensheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396285/
https://www.ncbi.nlm.nih.gov/pubmed/27800615
http://dx.doi.org/10.1002/1873-3468.12469