PPARγ agonists negatively regulate αIIbβ3 integrin outside‐in signaling and platelet function through up‐regulation of protein kinase A activity

ESSENTIALS: peroxisome proliferator‐activated receptor γ (PPARγ) agonists inhibit platelet function. PPARγ agonists negatively regulate outside‐in signaling via integrin αIIbβ3. PPARγ agonists disrupt the interaction of Gα13 with integrin β3. This is attributed to an upregulation of protein kinase A...

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Detalles Bibliográficos
Autores principales: Unsworth, A. J., Kriek, N., Bye, A. P., Naran, K., Sage, T., Flora, G. D., Gibbins, J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
PLATELETS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396324/
https://www.ncbi.nlm.nih.gov/pubmed/27896950
http://dx.doi.org/10.1111/jth.13578

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396324/
https://www.ncbi.nlm.nih.gov/pubmed/27896950
http://dx.doi.org/10.1111/jth.13578

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