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Reducing DNA context dependence in bacterial promoters

Variation in the DNA sequence upstream of bacterial promoters is known to affect the expression levels of the products they regulate, sometimes dramatically. While neutral synthetic insulator sequences have been found to buffer promoters from upstream DNA context, there are no established methods fo...

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Detalles Bibliográficos
Autores principales: Carr, Swati B., Beal, Jacob, Densmore, Douglas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396932/
https://www.ncbi.nlm.nih.gov/pubmed/28422998
http://dx.doi.org/10.1371/journal.pone.0176013