Design, synthesis and structure-activity relationship study of wollamide B; a new potential anti TB agent

Wollamide B is a cationic antimycobacterial cyclohexapeptide that exhibits activity against Mycobacterium bovis (M. bovis) (IC(50) of 3.1 μM). Aiming to define its structural activity relationship (SAR), optimizing potency and pharmacokinetic properties, libraries of analogues were synthesized follo...

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Detalles Bibliográficos
Autores principales: Asfaw, Henok, Laqua, Katja, Walkowska, Anna Maria, Cunningham, Fraser, Martinez-Martinez, Maria Santos, Cuevas-Zurita, Juan Carlos, Ballell-Pages, Lluís, Imming, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397059/
https://www.ncbi.nlm.nih.gov/pubmed/28423019
http://dx.doi.org/10.1371/journal.pone.0176088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397059/
https://www.ncbi.nlm.nih.gov/pubmed/28423019
http://dx.doi.org/10.1371/journal.pone.0176088

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