The promiscuous enzyme medium-chain 3-keto-acyl-CoA thiolase triggers a vicious cycle in fatty-acid beta-oxidation

Mitochondrial fatty-acid beta-oxidation (mFAO) plays a central role in mammalian energy metabolism. Multiple severe diseases are associated with defects in this pathway. Its kinetic structure is characterized by a complex wiring of which the functional implications have hardly been explored. Repetit...

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Detalles Bibliográficos
Autores principales: Martines, Anne-Claire M. F., van Eunen, Karen, Reijngoud, Dirk-Jan, Bakker, Barbara M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397069/
https://www.ncbi.nlm.nih.gov/pubmed/28369071
http://dx.doi.org/10.1371/journal.pcbi.1005461

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397069/
https://www.ncbi.nlm.nih.gov/pubmed/28369071
http://dx.doi.org/10.1371/journal.pcbi.1005461

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