Consecutive non-natural PZ nucleobase pairs in DNA impact helical structure as seen in 50 μs molecular dynamics simulations

Little is known about the influence of multiple consecutive ‘non-standard’ (Z, 6-amino-5-nitro-2(1H)-pyridone, and P, 2-amino-imidazo[1,2-a]-1,3,5-triazin-4(8H)-one) nucleobase pairs on the structural parameters of duplex DNA. P:Z nucleobase pairs follow standard rules for Watson–Crick base pairing...

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Detalles Bibliográficos
Autores principales: Molt, Robert W., Georgiadis, Millie M., Richards, Nigel G.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397145/
https://www.ncbi.nlm.nih.gov/pubmed/28334863
http://dx.doi.org/10.1093/nar/gkx144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397145/
https://www.ncbi.nlm.nih.gov/pubmed/28334863
http://dx.doi.org/10.1093/nar/gkx144

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