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Iron mediates catalysis of nucleic acid processing enzymes: support for Fe(II) as a cofactor before the great oxidation event

Life originated in an anoxic, Fe(2+)-rich environment. We hypothesize that on early Earth, Fe(2+) was a ubiquitous cofactor for nucleic acids, with roles in RNA folding and catalysis as well as in processing of nucleic acids by protein enzymes. In this model, Mg(2+) replaced Fe(2+) as the primary co...

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Detalles Bibliográficos
Autores principales: Okafor, C. Denise, Lanier, Kathryn A., Petrov, Anton S., Athavale, Shreyas S., Bowman, Jessica C., Hud, Nicholas V., Williams, Loren Dean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397171/
https://www.ncbi.nlm.nih.gov/pubmed/28334877
http://dx.doi.org/10.1093/nar/gkx171