Cargando…

DNA polymerase β uses its lyase domain in a processive search for DNA damage

DNA polymerase (Pol) β maintains genome fidelity by catalyzing DNA synthesis and removal of a reactive DNA repair intermediate during base excision repair (BER). Situated within the middle of the BER pathway, Pol β must efficiently locate its substrates before damage is exacerbated. The mechanisms o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Howard, Michael J., Rodriguez, Yesenia, Wilson, Samuel H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397181/ https://www.ncbi.nlm.nih.gov/pubmed/28119421 http://dx.doi.org/10.1093/nar/gkx047

Ejemplares similares

The deoxyribose phosphate lyase of DNA polymerase β suppresses a processive DNA synthesis to prevent trinucleotide repeat instability
por: Lai, Yanhao, et al.
Publicado: (2018)

Unencumbered Pol β lyase activity in nucleosome core particles
por: Rodriguez, Yesenia, et al.
Publicado: (2017)

Single-nucleotide base excision repair DNA polymerase activity in C. elegans in the absence of DNA polymerase β
por: Asagoshi, Kenjiro, et al.
Publicado: (2012)

Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage
por: Sabouri, Nasim, et al.
Publicado: (2008)

RNA-guided DNA base damage repair via DNA polymerase-mediated nick translation
por: Tsegay, Pawlos S, et al.
Publicado: (2022)

Metal-induced DNA translocation leads to DNA polymerase conformational activation
por: Kirby, Thomas W., et al.
Publicado: (2012)

PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage
por: Riccio, Amanda A., et al.
Publicado: (2016)

Polymerase η suppresses telomere defects induced by DNA damaging agents
por: Pope-Varsalona, Hannah, et al.
Publicado: (2014)

DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes
por: Sykora, Peter, et al.
Publicado: (2015)

Structural evidence for an essential Fe–S cluster in the catalytic core domain of DNA polymerase ϵ
por: ter Beek, Josy, et al.
Publicado: (2019)

DNA polymerase beta participates in DNA End-joining
por: Ray, Sreerupa, et al.
Publicado: (2018)

Recombinase and translesion DNA polymerase decrease the speed of replication fork progression during the DNA damage response in Escherichia coli cells
por: Tan, Kang Wei, et al.
Publicado: (2015)

Role of the Polymerase ϵ sub-unit DPB2 in DNA replication, cell cycle regulation and DNA damage response in Arabidopsis
por: Pedroza-Garcia, José Antonio, et al.
Publicado: (2016)

The human papillomavirus DNA helicase E1 binds, stimulates, and confers processivity to cellular DNA polymerase epsilon
por: Chojnacki, Michaelle, et al.
Publicado: (2018)

Synthetic lethality between BRCA1 deficiency and poly(ADP-ribose) polymerase inhibition is modulated by processing of endogenous oxidative DNA damage
por: Giovannini, Sara, et al.
Publicado: (2019)

Switching between polymerase and exonuclease sites in DNA polymerase ε
por: Ganai, Rais A., et al.
Publicado: (2015)

Constitutive fusion of ubiquitin to PCNA provides DNA damage tolerance independent of translesion polymerase activities
por: Pastushok, Landon, et al.
Publicado: (2010)

Sustained pigmentation causes DNA damage and invokes translesion polymerase Polκ for repair in melanocytes
por: Ghazi, Madeeha, et al.
Publicado: (2023)

DNA damage alters DNA polymerase δ to a form that exhibits increased discrimination against modified template bases and mismatched primers
por: Meng, Xiao, et al.
Publicado: (2009)

REV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase ζ
por: Tomida, Junya, et al.
Publicado: (2015)

The POLD3 subunit of DNA polymerase δ can promote translesion synthesis independently of DNA polymerase ζ
por: Hirota, Kouji, et al.
Publicado: (2015)

Roles of PCNA ubiquitination and TLS polymerases κ and η in the bypass of methyl methanesulfonate-induced DNA damage
por: Wit, Niek, et al.
Publicado: (2015)

Selective disruption of the DNA polymerase III α–β complex by the umuD gene products
por: Silva, Michelle C., et al.
Publicado: (2012)

I260Q DNA polymerase β highlights precatalytic conformational rearrangements critical for fidelity
por: Liptak, Cary, et al.
Publicado: (2018)

Polymerase manager protein UmuD directly regulates Escherichia coli DNA polymerase III α binding to ssDNA
por: Chaurasiya, Kathy R., et al.
Publicado: (2013)

Degradation of DNA damage-independently stalled RNA polymerase II is independent of the E3 ligase Elc1
por: Karakasili, Eleni, et al.
Publicado: (2014)

Multiple biochemical properties of the p53 molecule contribute to activation of polymerase iota-dependent DNA damage tolerance
por: Biber, Stephanie, et al.
Publicado: (2020)

Structural and functional determinants of the archaeal 8-oxoguanine-DNA glycosylase AGOG for DNA damage recognition and processing
por: Franck, Coste, et al.
Publicado: (2022)

The PIN domain of EXO1 recognizes poly(ADP-ribose) in DNA damage response
por: Zhang, Feng, et al.
Publicado: (2015)

The structure and duplex context of DNA interstrand crosslinks affects the activity of DNA polymerase η
por: Roy, Upasana, et al.
Publicado: (2016)

Bypass of DNA interstrand crosslinks by a Rev1–DNA polymerase ζ complex
por: Bezalel-Buch, Rachel, et al.
Publicado: (2020)

MutL binds to 3′ resected DNA ends and blocks DNA polymerase access
por: Borsellini, Alessandro, et al.
Publicado: (2022)

PARP1 changes from three-dimensional DNA damage searching to one-dimensional diffusion after auto-PARylation or in the presence of APE1
por: Liu, Lili, et al.
Publicado: (2017)

Functional interplay of DnaE polymerase, DnaG primase and DnaC helicase within a ternary complex, and primase to polymerase hand-off during lagging strand DNA replication in Bacillus subtilis
por: Rannou, Olivier, et al.
Publicado: (2013)

Inhibition of translesion DNA polymerase by archaeal reverse gyrase
por: Valenti, Anna, et al.
Publicado: (2009)

Loop 1 modulates the fidelity of DNA polymerase λ
por: Bebenek, Katarzyna, et al.
Publicado: (2010)

Strand displacement synthesis by yeast DNA polymerase ε
por: Ganai, Rais A., et al.
Publicado: (2016)

Saccharomyces cerevisiae DNA polymerase IV overcomes Rad51 inhibition of DNA polymerase δ in Rad52-mediated direct-repeat recombination
por: Cerqueira, Paula G, et al.
Publicado: (2023)

Interaction of human HelQ with DNA polymerase delta halts DNA synthesis and stimulates DNA single-strand annealing
por: He, Liu, et al.
Publicado: (2023)

The lyase activity of bifunctional DNA glycosylases and the 3′-diesterase activity of APE1 contribute to the repair of oxidized bases in nucleosomes
por: Maher, Robyn L, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_iql0io2bop0bnl79vqu4jm5tsv