Recognition but no repair of abasic site in single-stranded DNA by human ribosomal uS3 protein residing within intact 40S subunit

Isolated human ribosomal protein uS3 has extra-ribosomal functions including those related to base excision DNA repair, e.g. AP lyase activity that nicks double-stranded (ds) DNA 3΄ to the abasic (AP) site. However, the ability of uS3 residing within ribosome to recognize and cleave damaged DNA has...

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Detalles Bibliográficos
Autores principales: Grosheva, Anastasia S., Zharkov, Dmitry O., Stahl, Joachim, Gopanenko, Alexander V., Tupikin, Alexey E., Kabilov, Marsel R., Graifer, Dmitri M., Karpova, Galina G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397187/
https://www.ncbi.nlm.nih.gov/pubmed/28334742
http://dx.doi.org/10.1093/nar/gkx052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397187/
https://www.ncbi.nlm.nih.gov/pubmed/28334742
http://dx.doi.org/10.1093/nar/gkx052

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