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Tankyrase1-mediated poly(ADP-ribosyl)ation of TRF1 maintains cell survival after telomeric DNA damage

Oxidative DNA damage triggers telomere erosion and cellular senescence. However, how repair is initiated at telomeres is largely unknown. Here, we found unlike PARP1-mediated Poly-ADP-Ribosylation (PARylation) at genomic damage sites, PARylation at telomeres is mainly dependent on tankyrase1 (TNKS1)...

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Detalles Bibliográficos
Autores principales: Yang, Lu, Sun, Luxi, Teng, Yaqun, Chen, Hao, Gao, Ying, Levine, Arthur S., Nakajima, Satoshi, Lan, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397190/
https://www.ncbi.nlm.nih.gov/pubmed/28160604
http://dx.doi.org/10.1093/nar/gkx083