Amyloid β-Exposed Human Astrocytes Overproduce Phospho-Tau and Overrelease It within Exosomes, Effects Suppressed by Calcilytic NPS 2143—Further Implications for Alzheimer's Therapy

The two main drivers of Alzheimer's disease (AD), amyloid-β (Aβ) and hyperphosphorylated Tau (p-Tau) oligomers, cooperatively accelerate AD progression, but a hot debate is still ongoing about which of the two appears first. Here we present preliminary evidence showing that Tau and p-Tau are ex...

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Detalles Bibliográficos
Autores principales: Chiarini, Anna, Armato, Ubaldo, Gardenal, Emanuela, Gui, Li, Dal Prà, Ilaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397492/
https://www.ncbi.nlm.nih.gov/pubmed/28473749
http://dx.doi.org/10.3389/fnins.2017.00217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397492/
https://www.ncbi.nlm.nih.gov/pubmed/28473749
http://dx.doi.org/10.3389/fnins.2017.00217

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