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AFIR: A Dimensionless Potency Metric for Characterizing the Activity of Monoclonal Antibodies
For monoclonal antibody (mAb) drugs, soluble targets may accumulate several thousand fold after binding to the drug. Time course data of mAb and total target is often collected and, although free target is more closely related to clinical effect, it is difficult to measure. Therefore, mathematical m...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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John Wiley and Sons Inc.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397564/ https://www.ncbi.nlm.nih.gov/pubmed/28375563 http://dx.doi.org/10.1002/psp4.12169 |