MCL-1 is modulated in Crohn’s disease fibrosis by miR-29b via IL-6 and IL-8

The miR-29 family is involved in fibrosis in multiple organs, including the intestine where miR-29b facilitates TGF-β-mediated up-regulation of collagen in mucosal fibroblasts from Crohn’s disease (CD) patients. Myeloid cell leukemia-1 (MCL-1), a member of the B-cell CLL/Lymphoma 2 (BCL-2) apoptosis...

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Detalles Bibliográficos
Autores principales: Nijhuis, Anke, Curciarello, Renata, Mehta, Shameer, Feakins, Roger, Bishop, Cleo L., Lindsay, James O., Silver, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397660/
https://www.ncbi.nlm.nih.gov/pubmed/28190086
http://dx.doi.org/10.1007/s00441-017-2576-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397660/
https://www.ncbi.nlm.nih.gov/pubmed/28190086
http://dx.doi.org/10.1007/s00441-017-2576-1

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