Integrative modelling of TIR domain-containing adaptor molecule inducing interferon-β (TRIF) provides insights into its autoinhibited state

BACKGROUND: TRIF is a key protein in antiviral innate immunity, operating downstream of TLRs. TRIF activation leads to the production of interferon-β and pro-inflammatory cytokines. There is evidence from experiments to suggest that the N-terminal domain of TRIF binds to its TIR domain to avoid cons...

Descripción completa

Detalles Bibliográficos
Autores principales: Mahita, Jarjapu, Sowdhamini, Ramanathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397763/
https://www.ncbi.nlm.nih.gov/pubmed/28427457
http://dx.doi.org/10.1186/s13062-017-0179-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397763/
https://www.ncbi.nlm.nih.gov/pubmed/28427457
http://dx.doi.org/10.1186/s13062-017-0179-0

Ejemplares similares