Novel interactions of the von Hippel-Lindau (pVHL) tumor suppressor with the CDKN1 family of cell cycle inhibitors

Germline inactivation of the von Hippel-Lindau (VHL) tumor suppressor predisposes patients to develop different highly vascularized cancers. pVHL targets the hypoxia-inducible transcription factor (HIF-1α) for degradation, modulating the activation of various genes involved in hypoxia response. Hypo...

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Detalles Bibliográficos
Autores principales: Minervini, Giovanni, Lopreiato, Raffaele, Bortolotto, Raissa, Falconieri, Antonella, Sartori, Geppo, Tosatto, Silvio C. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397843/
https://www.ncbi.nlm.nih.gov/pubmed/28425505
http://dx.doi.org/10.1038/srep46562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397843/
https://www.ncbi.nlm.nih.gov/pubmed/28425505
http://dx.doi.org/10.1038/srep46562

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