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Oncodomains: A protein domain-centric framework for analyzing rare variants in tumor samples

The fight against cancer is hindered by its highly heterogeneous nature. Genome-wide sequencing studies have shown that individual malignancies contain many mutations that range from those commonly found in tumor genomes to rare somatic variants present only in a small fraction of lesions. Such rare...

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Detalles Bibliográficos
Autores principales: Peterson, Thomas A., Gauran, Iris Ivy M., Park, Junyong, Park, DoHwan, Kann, Maricel G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398485/
https://www.ncbi.nlm.nih.gov/pubmed/28426665
http://dx.doi.org/10.1371/journal.pcbi.1005428