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Observation of σ-pore currents in mutant hKv1.2_V370C potassium channels

Current through the σ-pore was first detected in hKv1.3_V388C channels, where the V388C mutation in hKv1.3 channels opened a new pathway (σ-pore) behind the central α-pore. Typical for this mutant channel was inward current at potentials more negative than -100 mV when the central α-pore was closed....

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Detalles Bibliográficos
Autores principales: Tyutyaev, Pavel, Grissmer, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398642/
https://www.ncbi.nlm.nih.gov/pubmed/28426823
http://dx.doi.org/10.1371/journal.pone.0176078