Glucotoxicity induces abnormal glucagon secretion through impaired insulin signaling in InR1G cells

The significance of glucagon in the pathophysiology of diabetes mellitus is widely recognized, but the mechanisms underlying dysregulated glucagon secretion are still unclear. Here, we explored the molecular mechanisms of glucagon dysregulation, using an in vitro model. Hamster-derived glucagon-secr...

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Detalles Bibliográficos
Autores principales: Katsura, Takashi, Kawamori, Dan, Aida, Eri, Matsuoka, Taka-aki, Shimomura, Iichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398759/
https://www.ncbi.nlm.nih.gov/pubmed/28426798
http://dx.doi.org/10.1371/journal.pone.0176271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398759/
https://www.ncbi.nlm.nih.gov/pubmed/28426798
http://dx.doi.org/10.1371/journal.pone.0176271

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