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Glucotoxicity induces abnormal glucagon secretion through impaired insulin signaling in InR1G cells
The significance of glucagon in the pathophysiology of diabetes mellitus is widely recognized, but the mechanisms underlying dysregulated glucagon secretion are still unclear. Here, we explored the molecular mechanisms of glucagon dysregulation, using an in vitro model. Hamster-derived glucagon-secr...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398759/ https://www.ncbi.nlm.nih.gov/pubmed/28426798 http://dx.doi.org/10.1371/journal.pone.0176271 |