A B(12)-dependent radical SAM enzyme involved in Oxetanocin-A biosynthesis

Oxetanocin-A (OXT-A, 1) is a potent antitumor, antiviral, and antibacterial compound. Biosynthesis of OXT-A has been linked to a plasmid-borne, Bacillus megaterium gene cluster that contains four genes, oxsA, oxsB, oxrA, and oxrB. Here, we show that the oxsA and oxsB genes are both required for the...

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Detalles Bibliográficos
Autores principales: Bridwell-Rabb, Jennifer, Zhong, Aoshu, Sun, He G., Drennan, Catherine L., Liu, Hung-wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398914/
https://www.ncbi.nlm.nih.gov/pubmed/28346939
http://dx.doi.org/10.1038/nature21689

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398914/
https://www.ncbi.nlm.nih.gov/pubmed/28346939
http://dx.doi.org/10.1038/nature21689

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