Improving animal welfare using continuous nalbuphine infusion in a long-term rat model of sepsis

BACKGROUND: Sepsis research relies on animal models to investigate the mechanisms of the dysregulated host response to infection. Animal welfare concerns request the use of potent analgesics for the Refinement of existing sepsis models, according to the 3Rs principle. Nevertheless, adequate analgesi...

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Detalles Bibliográficos
Autores principales: Jeger, Victor, Arrigo, Mattia, Hildenbrand, Florian F., Müller, Daniel, Jirkof, Paulin, Hauffe, Till, Seifert, Burkhardt, Arras, Margarete, Spahn, Donat R., Bettex, Dominique, Rudiger, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399012/
https://www.ncbi.nlm.nih.gov/pubmed/28429311
http://dx.doi.org/10.1186/s40635-017-0137-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399012/
https://www.ncbi.nlm.nih.gov/pubmed/28429311
http://dx.doi.org/10.1186/s40635-017-0137-2

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