IL-2-Mediated In Vivo Expansion of Regulatory T Cells Combined with CD154–CD40 Co-Stimulation Blockade but Not CTLA-4 Ig Prolongs Allograft Survival in Naive and Sensitized Mice

In recent years, regulatory T cells (Treg)-based immunotherapy has emerged as a promising strategy to promote operational tolerance after solid organ transplantation (SOT). However, a main hurdle for the therapeutic use of Treg in transplantation is their low frequency, particularly in non-lymphopen...

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Detalles Bibliográficos
Autores principales: Govender, Lerisa, Wyss, Jean-Christophe, Kumar, Rajesh, Pascual, Manuel, Golshayan, Dela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399033/
https://www.ncbi.nlm.nih.gov/pubmed/28484450
http://dx.doi.org/10.3389/fimmu.2017.00421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399033/
https://www.ncbi.nlm.nih.gov/pubmed/28484450
http://dx.doi.org/10.3389/fimmu.2017.00421

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