Maintenance of drug metabolism and transport functions in human precision-cut liver slices during prolonged incubation for 5 days

Human precision-cut liver slices (hPCLS) are a valuable ex vivo model that can be used in acute toxicity studies. However, a rapid decline in metabolic enzyme activity limits their use in studies that require a prolonged xenobiotic exposure. The aim of the study was to extend the viability and funct...

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Detalles Bibliográficos
Autores principales: Starokozhko, Viktoriia, Vatakuti, Suresh, Schievink, Bauke, Merema, Marjolijn T., Asplund, Annika, Synnergren, Jane, Aspegren, Anders, Groothuis, Geny M. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Toxicokinetics and Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399048/
https://www.ncbi.nlm.nih.gov/pubmed/27717970
http://dx.doi.org/10.1007/s00204-016-1865-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399048/
https://www.ncbi.nlm.nih.gov/pubmed/27717970
http://dx.doi.org/10.1007/s00204-016-1865-x

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