Integrating in vitro data and physiologically based kinetic (PBK) modelling to assess the in vivo potential developmental toxicity of a series of phenols

Toxicity outcomes derived in vitro do not always reflect in vivo toxicity values, which was previously observed for a series of phenols tested in the embryonic stem cell test (EST). Translation of in vitro data to the in vivo situation is therefore an important, but still limiting step for the use o...

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Detalles Bibliográficos
Autores principales: Strikwold, Marije, Spenkelink, Bert, de Haan, Laura H. J., Woutersen, Ruud A., Punt, Ans, Rietjens, Ivonne M. C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Toxicokinetics and Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399052/
https://www.ncbi.nlm.nih.gov/pubmed/27815601
http://dx.doi.org/10.1007/s00204-016-1881-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399052/
https://www.ncbi.nlm.nih.gov/pubmed/27815601
http://dx.doi.org/10.1007/s00204-016-1881-x

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