Cargando…

The anti-apoptotic Bcl-2 family protein A1/Bfl-1 regulates neutrophil survival and homeostasis and is controlled via PI3K and JAK/STAT signaling

Neutrophil granulocytes are innate effector cells of the first line of defense against pyogenic bacteria. Neutrophil lifespan is short, is prolonged by pro-inflammatory stimuli, controls functionality of the cells and can determine tissue damage. Experimental analysis of primary neutrophils is diffi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vier, J, Groth, M, Sochalska, M, Kirschnek, S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399193/ https://www.ncbi.nlm.nih.gov/pubmed/26890142 http://dx.doi.org/10.1038/cddis.2016.23

Ejemplares similares

Roscovitine-induced Apoptosis in Neutrophils and Neutrophil Progenitors Is Regulated by the Bcl-2-Family Members Bim, Puma, Noxa and Mcl-1
por: Gautam, Sanjivan, et al.
Publicado: (2013)

Correction: Roscovitine-induced Apoptosis in Neutrophils and Neutrophil Progenitors Is Regulated by the Bcl-2-Family Members Bim, Puma, Noxa and Mcl-1
por: Gautam, Sanjivan, et al.
Publicado: (2014)

A redox switch regulates the structure and function of anti-apoptotic BFL-1
por: Korshavn, Kyle J., et al.
Publicado: (2020)

BFL-1 expression determines the efficacy of venetoclax in MYC+/BCL2+ double hit lymphoma
por: Esteve-Arenys, Anna, et al.
Publicado: (2018)

Anti-Apoptotic Bfl-1 Is the Major Effector in Activation-Induced Human Mast Cell Survival
por: Ekoff, Maria, et al.
Publicado: (2012)

Bcl-2 is a better ABT-737 target than Bcl-xL or Bcl-w and only Noxa overcomes resistance mediated by Mcl-1, Bfl-1, or Bcl-B
por: Rooswinkel, R W, et al.
Publicado: (2012)

A1/Bfl-1 in leukocyte development and cell death
por: Ottina, Eleonora, et al.
Publicado: (2012)

Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1
por: Jenson, Justin M, et al.
Publicado: (2017)

hBfl-1/hNOXA Interaction Studies Provide New Insights on the Role of Bfl-1 in Cancer Cell Resistance and for the Design of Novel Anticancer Agents
por: Barile, Elisa, et al.
Publicado: (2016)

Last but not least: BFL-1 as an emerging target for anti-cancer therapies
por: Wang, Gaoyuan, et al.
Publicado: (2022)

Multiple Myeloma Relapse Is Associated with Increased NFκB Pathway Activity and Upregulation of the Pro-Survival BCL-2 Protein BFL-1
por: Spaan, Ingrid, et al.
Publicado: (2021)

The C-terminal region of Bfl-1 sensitizes non-small cell lung cancer to gemcitabine-induced apoptosis by suppressing NF-κB activity and down-regulating Bfl-1
por: Kim, Min-Kyoung, et al.
Publicado: (2011)

Application of the In Vitro HoxB8 Model System to Characterize the Contributions of Neutrophil–LPS Interaction to Periodontal Disease
por: Sochalska, Maja, et al.
Publicado: (2020)

Upregulation of bfl-1 is a potential mechanism of chemoresistance in B-cell chronic lymphocytic leukaemia
por: Olsson, A, et al.
Publicado: (2007)

Bfl-1 gene expression in breast cancer: its relationship with other prognostic factors.
por: Yoon, Ho-Sung, et al.
Publicado: (2003)

µ-Calpain Conversion of Antiapoptotic Bfl-1 (BCL2A1) into a Prodeath Factor Reveals Two Distinct alpha-Helices Inducing Mitochondria-Mediated Apoptosis
por: Valero, Juan García, et al.
Publicado: (2012)

Bim(S)-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins
por: Weber, Arnim, et al.
Publicado: (2007)

Removal of BFL-1 sensitises some melanoma cells to killing by BH3 mimetic drugs
por: Gangoda, Lahiru, et al.
Publicado: (2022)

Transcriptional regulation by STAT1 and STAT2 in the interferon JAK-STAT pathway
por: Au-Yeung, Nancy, et al.
Publicado: (2013)

STAT5 Is an Ambivalent Regulator of Neutrophil Homeostasis
por: Fiévez, Laurence, et al.
Publicado: (2007)

Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival
por: Sochalska, M, et al.
Publicado: (2016)

JAK/STAT signaling is necessary for cell monosis prior to epithelial cell apoptotic extrusion
por: Torres, Alba Y, et al.
Publicado: (2017)

8-Hydroxydaidzein Downregulates JAK/STAT, MMP, Oxidative Phosphorylation, and PI3K/AKT Pathways in K562 Cells
por: Wu, Pei-Shan, et al.
Publicado: (2021)

Differential effects of Vav‐promoter‐driven overexpression of BCLX and BFL1 on lymphocyte survival and B cell lymphomagenesis
por: Tuzlak, Selma, et al.
Publicado: (2018)

Ds tagging of BRANCHED FLORETLESS 1 (BFL1) that mediates the transition from spikelet to floret meristem in rice (Oryza sativa L)
por: Zhu, Qian-Hao, et al.
Publicado: (2003)

DOK3 maintains intestinal homeostasis by suppressing JAK2/STAT3 signaling and S100a8/9 production in neutrophils
por: Loh, Jia Tong, et al.
Publicado: (2021)

MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis
por: Sochalska, M, et al.
Publicado: (2017)

Synergistic effects of thalidomide and cisplatin are mediated via the PI3K/AKT and JAK1/STAT3 signaling pathways in cervical cancer
por: Liu, Cairu, et al.
Publicado: (2022)

JAK/STAT Activation: A General Mechanism for Bone Development, Homeostasis, and Regeneration
por: Damerau, Alexandra, et al.
Publicado: (2020)

A centric view of JAK/STAT5 in intestinal homeostasis, infection, and inflammation
por: Surbek, Marta, et al.
Publicado: (2021)

PI3K-AKT, JAK2-STAT3 pathways and cell–cell contact regulate maspin subcellular localization
por: Longhi, M. T., et al.
Publicado: (2021)

Manipulation of Neutrophils by Porphyromonas gingivalis in the Development of Periodontitis
por: Sochalska, Maja, et al.
Publicado: (2017)

BFL1 modulates apoptosis at the membrane level through a bifunctional and multimodal mechanism showing key differences with BCLXL
por: Flores-Romero, Hector, et al.
Publicado: (2018)

Vitamin K2 Improves Osteogenic Differentiation by Inhibiting STAT1 via the Bcl-6 and IL-6/JAK in C3H10 T1/2 Clone 8 Cells
por: Wang, Huakai, et al.
Publicado: (2022)

The molecular basis of JAK/STAT inhibition by SOCS1
por: Liau, Nicholas P. D., et al.
Publicado: (2018)

Neutrophils in STAT1 Gain-Of-Function Have a Pro-inflammatory Signature Which Is Not Rescued by JAK Inhibition
por: Parackova, Zuzana, et al.
Publicado: (2023)

Diversity of cell death signaling pathways in macrophages upon infection with modified vaccinia virus Ankara (MVA)
por: Klaas, Lioba, et al.
Publicado: (2021)

Computational models of the JAK1/2-STAT1 signaling
por: Gambin, Anna, et al.
Publicado: (2013)

JAK/STAT Pathway Mutations in T-ALL, Including the STAT5B N642H Mutation, are Sensitive to JAK1/JAK3 Inhibitors
por: Govaerts, Inge, et al.
Publicado: (2019)

JAKs and STATs in chemoresistance
por: Costa-Pereira, Ana P
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_ifttb9dbi03t4k084loj64isje