Verteporfin-induced formation of protein cross-linked oligomers and high molecular weight complexes is mediated by light and leads to cell toxicity

Verteporfin (VP) was first used in Photodynamic therapy, where a non-thermal laser light (689 nm) in the presence of oxygen activates the drug to produce highly reactive oxygen radicals, resulting in local cell and tissue damage. However, it has also been shown that Verteporfin can have non-photoact...

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Detalles Bibliográficos
Autores principales: Konstantinou, Eleni K., Notomi, Shoji, Kosmidou, Cassandra, Brodowska, Katarzyna, Al-Moujahed, Ahmad, Nicolaou, Fotini, Tsoka, Pavlina, Gragoudas, Evangelos, Miller, Joan W., Young, Lucy H., Vavvas, Demetrios G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399488/
https://www.ncbi.nlm.nih.gov/pubmed/28429726
http://dx.doi.org/10.1038/srep46581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399488/
https://www.ncbi.nlm.nih.gov/pubmed/28429726
http://dx.doi.org/10.1038/srep46581

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