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Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering

The generation of antibody conjugates with a loading of two modules is desirable for a host of reasons. Whilst certain antibody engineering approaches have been useful in the preparation of such constructs, a reliable method based on a native antibody scaffold without the use of enzymes or harsh oxi...

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Detalles Bibliográficos
Autores principales: Lee, Maximillian T. W., Maruani, Antoine, Richards, Daniel A., Baker, James R., Caddick, Stephen, Chudasama, Vijay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399535/
https://www.ncbi.nlm.nih.gov/pubmed/28451324
http://dx.doi.org/10.1039/c6sc03655d