Epithelial and non-epithelial Ptch1 play opposing roles to regulate proliferation and morphogenesis of the mouse mammary gland

Patched 1 (Ptch1) has epithelial, stromal and systemic roles in murine mammary gland organogenesis, yet specific functions remain undefined. Cre-recombinase-mediated Ptch1 ablation in mammary epithelium increased proliferation and branching, but did not phenocopy transgenic expression of activated s...

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Detalles Bibliográficos
Autores principales: Monkkonen, Teresa, Landua, John D., Visbal, Adriana P., Lewis, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399619/
https://www.ncbi.nlm.nih.gov/pubmed/28275010
http://dx.doi.org/10.1242/dev.140434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399619/
https://www.ncbi.nlm.nih.gov/pubmed/28275010
http://dx.doi.org/10.1242/dev.140434

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