Microsomal and Cytosolic Scaling Factors in Dog and Human Kidney Cortex and Application for In Vitro-In Vivo Extrapolation of Renal Metabolic Clearance

In vitro-in vivo extrapolation of drug metabolism data obtained in enriched preparations of subcellular fractions rely on robust estimates of physiologically relevant scaling factors for the prediction of clearance in vivo. The purpose of the current study was to measure the microsomal and cytosolic...

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Detalles Bibliográficos
Autores principales: Scotcher, Daniel, Billington, Sarah, Brown, Jay, Jones, Christopher R., Brown, Colin D. A., Rostami-Hodjegan, Amin, Galetin, Aleksandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399648/
https://www.ncbi.nlm.nih.gov/pubmed/28270564
http://dx.doi.org/10.1124/dmd.117.075242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399648/
https://www.ncbi.nlm.nih.gov/pubmed/28270564
http://dx.doi.org/10.1124/dmd.117.075242

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