Unexpected high prevalence of resistance-associated Rv0678 variants in MDR-TB patients without documented prior use of clofazimine or bedaquiline

Objectives: Resistance-associated variants (RAVs) in Rv0678, a regulator of the MmpS5-MmpL5 efflux pump, have been shown to lead to increased MICs of bedaquiline (2- to 8- fold) and clofazimine (2- to 4-fold). The prevalence of these Rv0678 RAVs in clinical isolates and their impact on treatment out...

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Detalles Bibliográficos
Autores principales: Villellas, Cristina, Coeck, Nele, Meehan, Conor J., Lounis, Nacer, de Jong, Bouke, Rigouts, Leen, Andries, Koen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400087/
https://www.ncbi.nlm.nih.gov/pubmed/28031270
http://dx.doi.org/10.1093/jac/dkw502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400087/
https://www.ncbi.nlm.nih.gov/pubmed/28031270
http://dx.doi.org/10.1093/jac/dkw502

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