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An unmodified wobble uridine in tRNAs specific for Glutamine, Lysine, and Glutamic acid from Salmonella enterica Serovar Typhimurium results in nonviability—Due to increased missense errors?

In the wobble position of tRNAs specific for Gln, Lys, and Glu a universally conserved 5-methylene-2-thiouridine derivative (xm(5)s(2)U34, x denotes any of several chemical substituents and 34 denotes the wobble position) is present, which is 5-(carboxy)methylaminomethyl-2-thiouridine ((c)mnm(5)s(2)...

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Detalles Bibliográficos
Autores principales: Nilsson, Kristina, Jäger, Gunilla, Björk, Glenn R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400242/
https://www.ncbi.nlm.nih.gov/pubmed/28430781
http://dx.doi.org/10.1371/journal.pone.0175092