The burden of trisomy 21 disrupts the proteostasis network in Down syndrome

Down syndrome (DS) is a genetic disorder caused by trisomy of chromosome 21. Abnormalities in chromosome number have the potential to lead to disruption of the proteostasis network (PN) and accumulation of misfolded proteins. DS individuals suffer from several comorbidities, and we hypothesized that...

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Detalles Bibliográficos
Autores principales: Aivazidis, Stefanos, Coughlan, Christina M., Rauniyar, Abhishek K., Jiang, Hua, Liggett, L. Alexander, Maclean, Kenneth N., Roede, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400264/
https://www.ncbi.nlm.nih.gov/pubmed/28430800
http://dx.doi.org/10.1371/journal.pone.0176307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400264/
https://www.ncbi.nlm.nih.gov/pubmed/28430800
http://dx.doi.org/10.1371/journal.pone.0176307

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