Mutation Supply and Relative Fitness Shape the Genotypes of Ciprofloxacin-Resistant Escherichia coli

Ciprofloxacin is an important antibacterial drug targeting Type II topoisomerases, highly active against Gram-negatives including Escherichia coli. The evolution of resistance to ciprofloxacin in E. coli always requires multiple genetic changes, usually including mutations affecting two different dr...

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Detalles Bibliográficos
Autores principales: Huseby, Douglas L., Pietsch, Franziska, Brandis, Gerrit, Garoff, Linnéa, Tegehall, Angelica, Hughes, Diarmaid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400412/
https://www.ncbi.nlm.nih.gov/pubmed/28087782
http://dx.doi.org/10.1093/molbev/msx052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400412/
https://www.ncbi.nlm.nih.gov/pubmed/28087782
http://dx.doi.org/10.1093/molbev/msx052

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