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Mutation Supply and Relative Fitness Shape the Genotypes of Ciprofloxacin-Resistant Escherichia coli
Ciprofloxacin is an important antibacterial drug targeting Type II topoisomerases, highly active against Gram-negatives including Escherichia coli. The evolution of resistance to ciprofloxacin in E. coli always requires multiple genetic changes, usually including mutations affecting two different dr...
Autores principales: | Huseby, Douglas L., Pietsch, Franziska, Brandis, Gerrit, Garoff, Linnéa, Tegehall, Angelica, Hughes, Diarmaid |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400412/ https://www.ncbi.nlm.nih.gov/pubmed/28087782 http://dx.doi.org/10.1093/molbev/msx052 |
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