EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent

In proliferating cells, where most Polycomb repressive complex 2 (PRC2) studies have been performed, gene repression is associated with PRC2 trimethylation of H3K27 (H3K27me3). However, it is uncertain whether PRC2 writing of H3K27me3 is mechanistically required for gene silencing. Here, we studied...

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Detalles Bibliográficos
Autores principales: Ai, Shanshan, Peng, Yong, Li, Chen, Gu, Fei, Yu, Xianhong, Yue, Yanzhu, Ma, Qing, Chen, Jinghai, Lin, Zhiqiang, Zhou, Pingzhu, Xie, Huafeng, Prendiville, Terence W, Zheng, Wen, Liu, Yuli, Orkin, Stuart H, Wang, Da-Zhi, Yu, Jia, Pu, William T, He, Aibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400508/
https://www.ncbi.nlm.nih.gov/pubmed/28394251
http://dx.doi.org/10.7554/eLife.24570

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400508/
https://www.ncbi.nlm.nih.gov/pubmed/28394251
http://dx.doi.org/10.7554/eLife.24570

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